Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine\nand is characterized by atrophy of intestinal villi. The manifestations of the disease improve following\na gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin\nmanifestations are described in CD patients. The present paper reviews all CD-associated skin\ndiseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved\nin these associations. Different hypotheses have been proposed to explain the possible mechanisms\ninvolved in every association between CD and cutaneous manifestations. An abnormal small\nintestinal permeability seems to be implicated in various dermatological manifestations. However,\nmost of the associations between CD and cutaneous diseases is based on case reports and case series\nand a few controlled studies. To better assess the real involvement of the cutaneous district in CD\npatients, large multicentric controlled clinical trials are required.
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